Giannantonio Spena

from December 2011
Consultant at the Division and Clinic of Neurosurgery, Spedali Civili and University of Brescia, Brescia, Italy 

October 1999
Graduated “cum laude” at the Medical Faculty of the Second University of Naples.
Residency in Neurosurgery at the Clinic of Neurosurgery, University of Genoa. 

November 2005- April 2006
Awake surgery and brain mapping for cerebral tumors in eloquent areas. Prof. H. Duffau, Neurosurgery
Division, Pitié-Salpêtrière Hospital, Paris, France 

May 2003- May 2004
Junior Consultant at the Pediatric Neurosurgical Division, G. Gaslini Institute, Genoa, Italy
October 2004 to October 2005
Junior Consultant at the Clinic of Neurosurgery, University Hospital of Geneva, Switzerland
June 2006- November 2011
Consultant at the Division of Neurosurgery, Civil Hospital, Alessandria, Italy

from September 2013
Contract professor at the Neurosurgery training program of the University of Milan

from July 2014
Hospital acknowledgment as skull base expert surgeon 

- Glioma surgery with extensive experience in awake surgery and direct brain mapping
- Posterior fossa tumors surgery (routine collaboration with ENT team for lateral skull base approaches)
-    Chiari malformation and syringomyelia surgery

- Spena G, Gatignol P, Capelle L, Duffau H. Superior longitudinal fsciculus subserves vestibular network in
humans. Neuroreport Sep 18;17(13):1403-6, 2006
- Spena G, Fasel J, De Tribolet N, Radovanovic I. Subfrontal endoscopic fenestration of lamina terminalis:
an anatomical study. Minimally Invasive Neurosurgery, 6 vol 51, 313-374, 2008
- Spena G, Bernucci C, Garbossa D, Valfrè V, Versari P. Clinical and radiological outcome of craniocervical
osteo-dural decompression for Chiari I-associated syringomyelia. Neurosurgical Review, DOI
- Spena G, Garbossa D, Barletta L, Prevost C, Versari P. Preoperative chemotherapy for infiltrative lowpagina
grade oligoastrocytoma: a useful strategy o maximize surgical resection. Neurol Med Chir (Tokio) 50, 408-
411, 2010
- Szelényi A, Bello L, Duffau H, Fava E, Feigl GC, Galanda M, Neuloh G, Signorelli F, Sala F.
Intraoperative electrical stimulation in awake craniotomy: methodological aspects of current practice.
Workgroup for Intraoperative Management in Low-Grade Glioma Surgery within the European Low-Grade
Glioma Network. Neurosurg Focus. 2010 Feb;28(2):E7. doi: 10.3171/2009.12.FOCUS09237. Review.
- Spena G, Nava A, Cassini F, Pepoli A, Bruno M, D'Agata F, Cauda F, Sacco K, Duca S, Barletta L, Versari
P. Preoperative and intraoperative brain mapping for the resection of eloquent-area tumors. A prospective
analysis of methodology, correlation, and usefulness based on clinical outcomes.
Acta Neurochir (Wien). 2010 Nov;152(11):1835-46.
- Spena G, Versari P. Bubbles in the head: a new method for brain retraction during craniotomy. Acta Neurochir
(Wien). 2011 Sep;153(9):1807-11.
- Comment on “Less invasive transjugular approach with Fallopian bridge technique for facial nerve protection
and hearing preservation in surgery of gloms jugular tumors. Nonaka Y, Fukushima T, Watanabe K,
Friedman AH, McElveen JT, Cunningham CD, Zomorodi AR. Neurosurg Rev 2013; 36(4):579-86
- Spena G, Garbossa D, Panciani PP, Griva F, Fontanella MM. Purely subcortical tumors in eloquent areas:
Awake surgery and cortical and subcortical electrical stimulation (CSES) ensure safe and effective surgery.
Clin Neurol Neurosurg. 2013 Mar 2.
- Garbossa D, Panciani PP, Angeleri R, Battaglia L, Tartara F, Ajello M, Agnoletti A, Versari P, Ducati A,
Fontanella M, Spena G. A retrospective two-center study of antiepileptic prophylaxis in patients with surgically
treated high-grade gliomas. Neurol India. 2013 Mar-Apr;61(2):131-7
- Beez T, Boge K, Wager M, Whittle I, Fontaine D, Spena G, Braun S, Szelényi A, Bello L, Duffau H, Sabel
M; European Low Grade Glioma Network. Tolerance of awake surgery for glioma: a prospective European
Low Grade Glioma Network multicenter study. Acta Neurochir (Wien). 2013 Jul;155(7):1301-8. doi:
10.1007/s00701-013-1759-0. Epub 2013 May 21.
- Comment on “Posterior condylar canals and posterior condylar emissary veins- a microsurgical and CT
anatomical study. Matsushima K, Kawashima M, Matsushima T, Hiraishi T, Noguchi T, Kuraoka A. Neurosurg
Rev 2014; 37(1): 115-126
- Spena G, D'Agata F, Panciani PP, Buglione di Monale M, Fontanella MM. Supratentorial gliomas in eloquent
areas: which parameters can predict functional outcome and extent of resection? PLoS One. 2013
Dec 5;8(12):e80916
- Spena G, Costi E, Panciani PP, Roca E, Migliorati K, Fontanella MM. Acute functional reactivation of the
language network during awake intraoperative brain mapping. Neurocase. 2014 May 7:1-5
- Buglione M, Spiazzi L, Saiani F, Costa L, Shehi B, Lazzari B, Uccelli C, Pasinetti N, Borghetti P, Triggini L,
Donadoni L, Pedretti S, Magrini SM; Neuro-Oncology Group, Spedali Civili, Brescia University, Brescia,
Italy. Three-dimensional conformal radiotherapy, static intensity-modulated and helical intensity-modulated
radiotherapy in glioblastoma. Dosimetric comparison in patients with overlap between target volumes and
organs at risk. Tumori. 2014 May-Jun;100(3):272-7
- Spena G, Panciani PP, Fontanella MM. Resection of supratentorial gliomas: the need to merge microsurgical
technical cornerstones with modern functional mapping concepts. An overview. Neurosurg Rev.
2014 Oct 21
- Stefini R, Zenga F, Esposito G, Bolzoni A, Tartara F, Spena G, Ambrosi C, Fontanella MM. Following the
canyon to reach and remove olfactory groove meningiomas: surgical experience.
J Neurosurg Sci. 2015 Mar 10
- Buglione M, Borghetti P, Pedretti S, Triggiani L, Fontanella MM, Spena G, Grisanti S, Liserre R, Poliani LP,
Gipponi S, Spiazzi L, Magrini SM. Post-surgical therapeutic approaches to glioblastoma patients submitted
to biopsy (BA) or "partial" resection (PR): the possibilities to treat also them without renunciations. Study
from the Brescia Neuro-Oncology Group. Radiol Med. 2015 Mar 15
- Rofes A, Spena G, Miozzo A, Fontanella MM, Miceli G. Advantages and disadvantages of intraoperative
language tasks in awake surgery: a three-task approach for prefrontal tumors. J Neurosurg Sci. 2015 Dec;
- Spena G, Panciani PP, Nicolosi F, Fontanella M. Minimally invasive subfrontal route for the resection of
medial temporal region intrinsic tumors. Acta Neurochir (Wien). 2015 Nov;157(11):1971-4
- Spena G. Functional neuro-oncological surgery: understanding brain functioning to enhance survival and
quality of life. J Neurosurg Sci. 2015 Dec;59(4):307. Epub 2015 Oct 20
- Altieri R, Zenga F, Fontanella MM, Cofano F, Agnoletti A, Spena G, Crobeddu E, Fornaro R, Ducati A,
Garbossa D. Glioma Surgery: Technological Advances to Achieve a Maximal Safe Resection. Surg
Technol Int. 2015 Nov
pagina !3
- Spena G, Schucht P, Seidel K, Rutte GJ, Freyschlag, D’Agata F, Costi E, Zappa F, Fontanella M, Fontaine
D, Almairac F, Cavallo M, De Bonis P, ConesaG, Foroglou N, Gil-Robles S, Mandonnet E, Martino J,
Picht T, VIEGAS C, Wager M, PALLUD J. Brain tumors in eloquent areas: A European multicenter survey
of intraoperative mapping techniques, intraoperative seizures occurrence, and antiepileptic drug prophylaxis.
Neurosurg Rev. 2017 Apr;40(2):287-298
-    Bertuccio A, Robba C, Spena G, Versari PP. Intracranial and Spinal Dural Arterio-Venous Fistula (DAVF): A Surgical Series of 107 Patients. Acta Neurochir Suppl. 2016;123:177-83
-    Grisanti S, Ferrari VD, Buglione M, Agazzi GM, Liserre R, Poliani L, Buttolo L, Gipponi S, Pedersini R, Consoli F, Panciani P, Roca E, Spena G, Triggiani L, Berruti A; Gruppo Neuro-Oncologico Bresciano. Second line treatment of recurrent glioblastoma with sunitinib: results of a phase II study and systematic review of literature. J Neurosurg Sci. 2016 Sep 28
-    Rofes A, Spena G, Talacchi A, Santini B, Miozzo A, Miceli G.Mapping nouns and finite verbs in left hemisphere tumors: a direct electrical stimulation study. Neurocase. 2017 Apr;23(2):105-113
-    Rofes A, Mandonnet E, Godden J, Baron MH, Colle H, Darlix A, de Aguiar V, Duffau H, Herbet G, Klein M, Lubrano V, Martino J, Mathew R, Miceli G, Moritz-Gasser S, Pallud J, Papagno C, Rech F, Robert E, Rutten GJ, Santarius T, Satoer D, Sierpowska J, Smits A, Skrap M, Spena G, Visch E, De Witte E, Zetterling M, Wager M. Survey on current cognitive practices within the European Low-Grade Glioma Network: towards a European assessment protocol. Acta Neurochir (Wien). 2017 Jul;159(7):1167-1178
-    Technical principles of direct bipolar electrostimulation for cortical and subcortical mapping in awake craniotomy. Pallud J, Mandonnet E, Corns R, Dezamis E, Parraga E, Zanello M, Spena G. Neurochirurgie. 2017 Jun;63(3):158-163
-    Altieri R, Hirono S, Duffau H, Ducati A, Fontanella M, LA Rocca G, Melcarne A, Panciani PP, Spena G, Garbossa D. Natural history of de novo High Grade Glioma: first description of growth parabola. J Neurosurg Sci. 2017 Jul 26.
-    Mandonnet E, Anract P, Martin E, Roujeau T, Spena G, Cormier-Daire V, Duffau H, Baujat G; CollaboratorsBrain and skull base MRI findings in patients with Ollier-Maffucci disease: A series of 12 patient-cases. Clin Neurol Neurosurg. 2017 Sep
-    Spena G, Sorrentino T, Altieri R, Redaelli de Zinis L, Stefini R, Panciani PR, Fontanella M. Early-career surgical practice for cerebellopontine angle tumors in the era of radiosurgery. Journal of Neurological Surgery Part B: Skull Base, in press

1. Giannantonio Spena, Antonio Pepoli, Marcella Bruno, Federico D’Agata, Franco Cauda, Katiuscia Sacco,
Sergio Duca and Pietro Versari (2011). Multimodal Approach to the Surgical Removal of Gliomas in Eloquent
Brain Regions, Advances in the Biology, Imaging and Therapies for Glioblastoma, Prof. Clark Chen
(Ed.), ISBN: 978-953-307-284-5, InTech, DOI: 10.5772/24446.

2. Trattamento chirurgico: derivazione ventricolo-peritoneale e ventricolo-atriale. 
In Idrocefalo normoteso I edizione (2016) PANCIANI P. P., FONTANELLA M. M.
ISBN-13 978-88-7711-863-9

3. Management of Chiari Malformation. In “Surgery of the Cranio-Vertebral Junction”, Tessitore/Dehdashti/Schonauer/Thome. Springer, In press

Invited speaker
-    VIII° Congresso della Società Italiana di Neurologia e Neurochirurgia  (SNO). Chirurgia dei tumori cerebrali in area eloquente, 24.01.2009, Ospedale Civile, Alessandria

-    Chirurgia delle metastasi cerebrali. Facoltà di Medicina, Università del Piemonte Orietale, Novara, 9.2.2009

-    Awake surgery per i tumori cerebrali in area eloquente. Società Italiana di Neurologia, Cuneo, 6-7.11.2009

-    Up to date sulle malattie rare. Trattamento chirurgico della m. Chiari I e Siringomielia. Ospedale Civile, Alessandria 08.02.2010

-    Neuroimaging dei tumori cerebrali: i bisogni del neurochirurgo. Ospedale Koelliker, Torino, 15.05.2010

-    Corpectomia cervical step-by-step. In “Cadaver lab of cervical spine approaches”. Dipartimento di Anatomia, Università di Vienna, Austria, 15-17-02.2011

-    Awake Brain Surgery: dalla chirurgia alla ricerca. Università di Torino, 14.06.2013

-    Sindrome di Chiari I e Siringomielia. Aspetti clinici e chirurgici. Domus Salutis, Brescia, 15.05.2013

-    Awake surgery e mapping intraoperatorio: utilità neurooncologica e modello per lo studio delle funzioni cerebrali. Lezione presso il corso PhD di Fisiologia Umana, Università di Milano, 25.05.2013

-    Glioblastoma: up to date su nuove terapie. Università di Milano, 15.04.2014

-    Approcci chirurgici alla spondilolistesi lombare: PLF, PLIF, TLIF. “How we do it” in Brescia. Sezione spinale della SINCH, Catania, 5-6-7.06.2014

-    Tumori intramidollari spinali. In “Strategie di management e tecniche chirurgiche in chirurgia spinale: evitare e prevenire i fallimenti”. Ferrara, 12.12.2014

-    DTI challenge. Italian chapter dell’ISMRM. Verona, 16-17.04.2015

-    Supratentorial gliomas in eloquent areas: Can we predict extent of resection and functional outcome? EANS 18-21 Ottobre, Madrid, Spagna

-    La siringomielia. Simposio su dolore neuropatico. NH Hotel Torino 23-24 Ottobre, Pfizer

-    Malformazione di Chiari I e Siringomielia: a che punto siamo e dove stiamo andando. Meeting per il 10° anniversario dell’AISMAC (Associazione Italiana Siringomielia ed Arnold-Chiari). 21 Novembre, Palazzo Capris, Torino

-    Approcci laterali al basicranio medio e posteriore. Università di Torino, 10-12 Marzo 2016

- Indicazioni al trattamento chirurgico negli ematomi intracerebrali. “Gestione delle Urgenze in Neurochirurgia”, Fondazione Policlinico IRCCS, Milano, 05.12.2016

-    Far lateral approach and extended pterional approach. 54th W. Laugheed Microsurgical Course, Western Hospital and University of Toronto, Canada. 1-5 Maggio 2017

-    Gliomi cerebrali: strategie terapeutiche combinate. Venezia 25-26 Maggio 2017.


Member of the Advisory Board of the Journal of Neurosurgical Sciences

Member of: 
- Italian Society of Neurosurgery (SINCH)
-    European association of neurosurgical societies (EANS)
-    Congress of Neurological Surgeon (CNS)
-    Section on Tumors (American association of neurological surgeons, AA